Overview
The increasing demand for 68Ga motivated the development of cyclotron production methods. Liquid
targets offer simple installation and lower investment. The workflow is similar to the fluorine
production, but yields are low. Solid target systems are capable of producing much higher activity but
are more complicated to install and to operate.
SynIQ has developed the d.o.t.s. target to combine the benefits of solid- and liquid targets. The d.o.t.s.
target operates with disposable preloaded solid target holders, tested up to 50 microampere beam
current. After irradiation, the target material is automatically dissolved in the target system and
transferred to a hotcell via PEEK capillary. Installation is simple, operation is controlled by a PLC.
Yield
| Produced 68Ga activity at EOB (GBq) | ||||
| Target material: 40mg 68Zn | Irradiation time | |||
| 10 min | 60 min | 120 min | 180 min | |
| GE PETtrace (50 uA) | 6.8 | 34.4 | 52.3 | 60.0 |
| GE Minitrace (10 uA) | 1.9 | 9.4 | – | – |
| GE Minitrace (30 uA) | 24.0 | |||
Quality
| Quality of produced 68Ga | ||
| Quality parameter | Ph.EUR. requirement | d.o.t.s. target result |
| Identification by gamma spectrometry | Peak at 0.511 MeV | Confirmed |
| Appearance | Clear and colorless | Confirmed |
| t1/2 | 62 – 74 min | 67.87 ± 0.18 min |
| pH | <2 | <2 |
| Iron content | <10 µg/GBq | 0.019 ± 0.005 µg/GBq |
| Zinc content | <10 µg/GBq | 0.061 ± 0.027 µg/GBq |
| Bacterial endotoxins | <175 IU/V | Not tested |
| Radionuclidic purity | > 98% | 99.997 % |
| Ga-66/67 content | < 2% | 0.003 % |
| Other radionuclidic impurities | < 0.1% | Not detected |
| TLC | > 95% 68Ga3+ | 99.90% |
| Volume | – | 5 ml |
| HCl concentration | > 0.01 M | 0.1 M |